Platelet-Rich Plasma (PRP)

Platelet-Rich Plasma (PRP)

PRP is a volume of the plasma fraction of autologous blood having a platelet concentration above baseline. It is produced from a patient’s own blood obtained by venipuncture (blood collection) as one would  undergo for a pathology test.

PRP can be used in the treatment of osteoarthritis and tendinopathies.

In the treatment of osteoarthritis PRP can improve pain and function for up to 12-18 months. It is not chondroprotective or chondroregenerative in that it does not prevent further cartilage loss or cause cartilage regrowth. A PRP low in leukocytes, leukocyte-poor platelet-rich plasma (LP-PRP), is the ideal preparation for treating osteoarthritis. Postinjection patients may undertake activity according to pain. At 6 months postinjection patients can expect to be experiencing 50% improvements in pain and function. Several recent systematic reviews and meta-analyses have shown that PRP is probably more effective than the hyaluronic acid (HA) preparations.

In the treatment of tendinopathies (tendon disease) PRP can cause healing by causing collagen regrowth. A PRP high in leukocytes, leukocyte-rich platelet-rich plasma (LP-PRP), is the ideal preparation for treating tendinopathies. PRP should only be injected on a single occasion as repeated injections have been shown to be ineffective. If a single injection is ineffective a subsequent injection is unlikely to be any more effective. PRP should be injected intratendinously, that is into the tendon, which is only achievable if the tendinopathy is degenerative and ‘high-grade’ with intrasubstance tears, and under ultrasound guidance. Postinjection patients need to continue with an eccentric strengthening program with healing occurring over a period of 12 weeks.

The injection of PRP carries the risks of infection and postinjection flaring of pain and is a clinic-based procedure.

YCellBio, tendinopathy, PRP, platelet-rich plasma, leukocyte-rich

YCellBio, a commercially available system capable of producing Leukocyte-Rich Platelet-Rich Plasma required for treating high-grade degenerative tendinopathies resistant to conservative management




Plantar Fasciitis

Patellar Tendinoapathy

Achillles Tendinopathy and Enthesopathy

Achilles Paratenonitis

Extracorporeal Shock-Wave Therapy (ESWT)

US Guided Injection

Platelet Rich Plasma (PRP)/Preparation Rich in Growth Factors (PRGF)


Mesenchymal Stem Cells